how it works

Even though it might look like an energy drink, Synapse stands apart from anything else you’ll find on a shelf for a few reasons. What might surprise you the most is that a can of Synapse contains exactly 0mg of caffeine – we left it out because Synapse doesn’t need it, and we don’t think you do either. After all, caffeine might make you feel less tired for a while, but we all know what happens when it wears off – that infamous crash. You’re wondering how Synapse can possibly provide you with focus and energy if it doesn’t even contain caffeine? The answer is simple: we use even more effective natural ingredients.

The secret is a molecule called acetylcholine, which is used by your brain for maintaining attention and focus as well as for forming new memories and learning new material. By using ingredients which work together to increase acetylcholine release in the brain through natural processes, Synapse works to optimize your brain’s natural function. Combining this increase in acetylcholine levels with our proprietary support matrix lets Synapse prime your brain for attentive, focused work and faster learning, which can lead to greatly increased mental performance across the board. Still want to learn more? You can click on each of our individual ingredients below to read about how they work to help deliver that indescribable Synapse feeling – we like to call it brilliance on demand!

memory + focus

Synapse uses highly effective natural ingredients to optimize the way the brain stores and processes information – increase your subjective sense of focus and improve your memory function on a cellular level.

Huperzia Serrata
focus, memory, &

This moss, which is found predominantly in China, is what is known as an acetylcholinesterase inhibitor, which simply put means that it helps to prevent your brain from breaking down the acetylcholine it has already released. Higher levels of acetylcholine have been implied in increased memory retention, and one of the most effective ways to increase the amount of acetylcholine in the brain is to reduce the speed with which the brain can remove it once it has been used to send a signal, effectively ensuring that the signal sticks around long enough to be “heard.”

Bacopa Monnieri
focus, memory, &

Known more commonly as water hyssop, this aquatic herb is also an acetylcholinesterase inhibitor, but is much more effective as an activator of choline acetyltransferase – that is to say, it increases the rate at which your brain can produce new acetylcholine, as well as slightly increasing the amount of acetylcholine each neuron will release in response to a stimulus. When paired with Huperzia Serrata, its effects on the brain’s cholinergic pathways are profound and overwhelmingly positive.

focus, memory, &

Found naturally within the brain as well as in both soybeans and sunflowers, Alpha-GPC is an extremely bioavailable source of choline, which is one of the necessary building blocks for the creation of acetylcholine. It also works to mildly increase the amount of acetylcholine that is released by neurons, properties which both work to strongly support the effects of our other cholinergic ingredients, huperzia serrata and bacopa monnieri.


Instead of relying on caffeine to keep you awake, Synapse includes ingredients that work to help your body generate energy more efficiently on a biological level – that means no jitters and no crash.

Agave Nectar
sweetness &

Every can of Synapse contains a touch of organic dark agave nectar, but this isn’t there just as a low-glycemic index sweetener. Agave nectar is composed mostly of monosaccharides (the most basic form of carbohydrate) which are the preferred energy source for the brain. These simple carbohydrates are used as fuel to replenish the ion balance of the billions of neurons in the human brain.

Citrulline Malate
energy production, blood flow, &
fatigue reduction

This compound is derived from a naturally-occurring amino acid which is primarily found in melons combined with an organic acid which is found predominantly in apples. It acts to increase the amount of energy your cells have to perform work on a fundamental level – it speeds up the rate at which your body’s cells can produce ATP, which is the molecule created in the mitochondria (read: the powerhouse of the cell!) ATP is used by every cell in your body for energy, as well as increasing the efficiency of this process. Additionally, citrulline supplementation improves blood flow and reduces fatigue.

stamina, blood flow, energy production

Synapse contains a highly soluble and bioavailable form of creatine, arguably the most well-researched supplement of all time. It acts as a vasodilator – it increases the rate of blood flow in your body to help all of our other ingredients to get to your brain at a faster rate, which is why a can of Synapse works so quickly. It also works along with citrulline malate to increase the rate at which your cells can produce ATP on a cellular level.

Acetyl L-Carnitine
alertness, antioxidant, & energy production

Also known by its abbreviation, ALCAR, this potent amino acid is capable of increasing the levels of a number of different neurotransmitters (particularly acetylcholine) as well as up-regulating the production of energy in the cells and improving the overall function and efficiency of the mitochondria. It has also been demonstrated to have positive overall effects on markers of learning, which is likely due to its cholinergic and antioxidant properties.

Alpha Lipoic Acid
blood, oxygenation, &

Found in high concentrations in leafy green vegetables such as spinach and broccoli, this nutrient plays an important role in energy metabolism, a role which it fulfills through its powerful antioxidant properties as well as its ability to increase the amount of oxygen consumed by the body from the bloodstream. This increase in capacity is important because the brain uses roughly a quarter of the body’s oxygen supply. It has also been implied in reducing the amount of damage incurred by brain cells from oxygen use during normal operation, which helps to mitigate some of the underlying causes of age-related cognitive decline.


Having a high stress day? Instead of making that anxiety worse with caffeine, Synapse includes ingredients that have been shown to reduce anxiety in as little as 5 minutes, leaving your mind free to do what you do best – achieve.

calm, fatigue reduction, &
blood flow

This berry has long been used in both Chinese and Russian culture to combat fatigue and promote feelings of wellness. These feelings come from its properties as a potent antioxidant as well as its ability to reduce circulating levels of stress hormones such as corticosterone. It also works to increase blood flow to all areas of the body and is a mild acetylcholinesterase inhibitor itself, which only increases the synergy of our blend even further.

calm, blood pressure reduction,

L-Theanine, first discovered in green tea, is a particularly interesting compound which exists naturally within your brain that works to reduce anxiety by being structurally similar enough to glutamate, the brain’s most prevalent excitatory neurotransmitter, to bind to the same cells, but just different enough that it actually blocks the excitatory effects. This instead promotes a feeling of calmness and well-being that is well-documented, an effect which is strengthened by the fact that L-theanine also promotes the production of GABA, the brain’s primary inhibitory neurotransmitter. L-theanine has also been shown to reduce the profound increase in blood pressure that many people experience in stressful situations. Interestingly enough, all of these effects combine to mildly increase measures of both focus and attention in humans, which can be attributed to the fact that most people tend to perform better in a state of relaxed alertness when compared to their performance in a highly stressful situation.

supplement facts